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Jul 15

DAEDRA: A language model for predicting outcomes in passive pharmacovigilance reporting

Over the recent years, the emergence of large language models (LLMs) has given rise to a proliferation of ___domain-specific models that are intended to reflect the particularities of linguistic context and content as a correlate of the originating ___domain. This paper details the conception, design, training and evaluation of DAEDRA, a LLM designed to detect regulatory-relevant outcomes (mortality, ER attendance and hospitalisation) in adverse event reports elicited through passive reporting (PR). While PR is a highly cost-efficient way of eliciting information from a wide and diverse audience -- typically including not only physicians and healthcare providers but also patients, family members and other lay stakeholders --, this diversity makes PR corpora difficult to analyse. Generic language models may not capture the complex clinical dimensions while specific clinical or biomedical models may not perform well on lay reports. To evaluate the utility of a subdomain-specific language model, an adaptive training approach was adapted, wherein base language model candidates were evaluated on a subset of the corpus, and the best performer was trained on the entire corpus. This yielded a small but significant improvement in F_1 (+1%), precision (+2.5%) and recall (+3.8%), at a relatively low training cost and a single-day training time. Subdomain-specific LLMs continue to be viable options for better results when analysing highly specialised corpora.

  • 1 authors
·
Feb 10, 2024

FLARE-AI: Flaw Reporting for AI

Flaw reporting for deployed AI systems is fundamental to identifying system failures and improving AI safety. Yet the AI reporting ecosystem is fragmented: researchers who identify flaws often do not know what or where to report, and groups who receive reports rarely share them with other relevant stakeholders. As a result, good-faith reporters duplicate effort by submitting many different forms, and recipients lack standardized, triage-ready information. We audit 12 reporting systems published by AI developers, cybersecurity groups, and AI flaw aggregators, identifying five recurring design challenges spanning discoverability, scope, information collection, coordination, and guidance for strict-liability cases. Building on this analysis and feedback from 49 experts across 32 organizations representing developers, security researchers, and ecosystem coordinators, we introduce FLARE-AI, an open-source AI flaw reporting system designed for interoperability with existing systems. FLARE-AI streamlines flaw report creation by collecting triage-relevant information through conditional logic and early classification, then enables optional dissemination of standardized, machine-readable reports to multiple developers, coordinators, and incident registries from a single submission. By lowering barriers to reporting AI flaws and improving interoperability across stakeholders, FLARE-AI helps break down silos and accelerate remediation across the AI ecosystem.

  • 18 authors
·
Jun 29